Microsomal activation

The mass spectrum of the unknown compound suggested that it was a hydroxylated derivative of SL. Incubation of mitochondrial preparations with 7 alpha-thio-SL also resulted in the formation of a polar metabolite, but the latter had a different HPLC retention time than that of the SL metabolite. Formation of the polar SL metabolite was prevented by metyrapone, an 11 beta-hydroxylase inhibitor, and was greatest in mitochondria from the adrenal zone having the highest 11 beta-hydroxylase activity.

Invest New Drugs 1, 27—32 Download citation. Issue Date : March Anyone you share the following link with will be able to read this content:.

Sorry, a shareable link is not currently available for this article. Provided by the Springer Nature SharedIt content-sharing initiative. Skip to main content. Search SpringerLink Search. Summary A commercially available preparation of livers from rats can be used to activate cyclophosphamide and DTIC in vitro. References 1. J Clin Invest —, Google Scholar 4. Science —, Google Scholar 5. Cancer —, Google Scholar 6. Biochem Pharmacol —13, Google Scholar 7. Mutat Res —, Google Scholar 8.

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Download references. You can also search for this author in PubMed Google Scholar. Correspondence to T Wu. Supplementary Information accompanies the paper on the Oncogene website. Reprints and Permissions. Lu, D. Oncogene 31, — Download citation.

Received : 17 January Revised : 02 May Accepted : 26 May Published : 11 July Issue Date : 16 February Anyone you share the following link with will be able to read this content:. Sorry, a shareable link is not currently available for this article. Provided by the Springer Nature SharedIt content-sharing initiative.